Last Updated: 2/7/25
Note: It's simple and straightforward: the best of the best chemistry in cinema history. In order to be considered, it must be at least two people in the same film, regardless of the rating I've given.

Multiple parts (i.e. duology, trilogy, etc.) can be put together as one if there's a continuation in the narrative. Miniseries and telefilms are fair game, but anything made after the year 2000 and documentaries are excluded.

This list is based on what I have seen so far and is limited to the top 45 with 0 honorable mentions in that order and some, if any, notable exceptions to the rule. While ranking the duos, trios, etc., I am thinking about their chemistry; the more instant the connection is, the better.

1. Paul Newman and Robert Redford
Butch Cassidy and the Sundance Kid (1969)

2. Danny Glover and Mel Gibson
Lethal Weapon Trilogy (1987, 1989, 1992)

3. Jon Voight and Dustin Hoffman
Midnight Cowboy (1969)

4. Warren Beatty and Faye Dunaway
Bonnie and Clyde (1967)

5. Humphrey Bogart and Lauren Bacall
To Have and Have Not (1944)

6. Humphrey Bogart and Ingrid Bergman
Casablanca (1942)

7. 4077th MASH Unit
M*A*S*H (1970)

8. Sylvester Stallone and Kurt Russell
Tango & Cash (1989)

9. Bonita Granville and Frankie Thomas
Nancy Drew Quadrilogy (1938, 1939)

10. James Caan and Billy Dee Williams
Brian's Song (1971)

11. Twelve Angry Men
12 Angry Men (1957)

12. Tim Robbins and Morgan Freeman
The Shawshank Redemption (1994)

13. Mickey Rourke and Kim Basinger
9½ Weeks (1986)

14. Steve Martin and John Candy
Planes, Trains & Automobiles (1987)

15. Donald Sutherland and Julie Christie
Don't Look Now (1973)

16. Robert Mitchum and Jane Russell
His Kind of Woman (1951)

17. Michael McKean, Harry Shearer, and Christopher Guest
This Is Spinal Tap (1984)

18. Secaucus 7
Return of the Secaucus 7 (1979)

19. Kevin Bacon and Fred Ward
Tremors (1990)

20. Clint Eastwood and Clyde
Every Which Way But Loose Duology (1978, 1980)

21. Basil Radford and Naunton Wayne
The Lady Vanishes (1938), Night Train to Munich (1940)

22. Paul Le Mat and Mackenzie Phillips
American Graffiti (1973)

23. Sean Connery and Michael Caine
The Man Who Would Be King (1975)

24. Richard Gere and Julia Roberts
Pretty Woman (1990)

25. Jean-Paul Belmondo and Jean Seberg
À bout de souffle (1960)

26. Marlon Brando and Vivien Leigh
A Streetcar Named Desire (1951)

27. Richard Dreyfuss, Roy Scheider, and Robert Shaw
Jaws (1975)

28. D.B. Sweeney and Moira Kelly
The Cutting Edge (1992)

29. Dennis Hopper, Jack Nicholson, and Peter Fonda
Easy Rider (1969)

30. Dustin Hoffman and Tom Cruise
Rain Man (1988)

31. John Travolta and Uma Thurman
Pulp Fiction (1994)

32. Patrick Swayze and Jennifer Grey
Dirty Dancing (1987)

33. Jaime Sanchez, Ernest Borgnine, William Holden, Warren Oates, Ben Johnson, and Edmond O'Brien
The Wild Bunch (1969)

34. Jennifer Jones and Charlton Heston
Ruby Gentry (1952)

35. Melanie Lynskey and Kate Winslet
Heavenly Creatures (1994)

36. Sidney Poitier and Rod Steiger
In the Heat of the Night (1967)

37. Keanu Reeves and Patrick Swayze
Point Break (1991)

38. Julia Ormond and Tim Roth
Captives (1994)

39. Diana Ross and Billy Dee Williams
Mahogany (1975)

40. James Spader and Andie MacDowell
Sex, Lies, and Videotape (1989)

41. Woody Harrelson and Juliette Lewis
Natural Born Killers (1994)

42. Ted Danson and Isabella Rossellini
Cousins (1989)

43. Willem Dafoe and Mary Elizabeth Mastrantonio
White Sands (1992)

44. Michael J. Fox and Christopher Lloyd
Back to the Future Trilogy (1985, 1989, 1990)

45. Seann William Scott and Ashton Kutcher
Dude, Where's My Car? (2000)

Notable Exception: Evan Rachel Wood and Nikki Reed: Thirteen (2003)